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KMID : 0370220220660030115
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Yakhak Hoeji
2022 Volume.66 No. 3 p.115 ~ p.124
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Current Trends in Causes and Mechanisms of Pruritus Induced by Systemic Diseases
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Park Soh-Yeon
Shim Won-Sik
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Abstract
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Pruritus is a sensation that evokes a desire to scratch the skin. In particular, pruritus can be a burden foraffected people when it becomes severe and chronic, as it deteriorates the quality of life. Dermatological diseases such asatopic dermatitis are mostly recognized as major pruritus-related disorders. Surprisingly, some non-dermatological systemicdiseases may can also cause evoke pruritus. In this review, we summarized the underlying causes and mechanisms of threenon-dermatological pruritus-related systemic diseases that are not related to dermatological pruritus: including chronickidney disease, cholestatic liver disease, and neoplasm. In addition, we discussed recent research observations and noveltherapeutic strategies are discussed.
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KEYWORD
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Pruritus, Systemic diseases, Chronic kidney disease, Cholestasis, Neoplasm
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